Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices Broth micro-dilution reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases

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Hardcopy , PDF

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English

Published date

07-07-2020

Publisher

British Standards Institution

This document describes one reference method, broth micro-dilution, for determination of MICs.

This document describes one reference method, broth micro-dilution, for determination of MICs. The MIC can be a guide for the clinician, and reflects the activity of the drug under the described test conditions, by taking into account other factors, such as drug pharmacology, pharmacokinetics, or bacterial resistance mechanisms. This allows categorisation of bacteria as “susceptible?? (S), “intermediate?? (I), or “resistant?? (R). In addition, MIC distributions can be used to define wild type or non-wild type bacterial populations. Although clinical interpretation of the MIC value is beyond the scope of this document, modifications of the basic method are required for certain antimicrobial agent - bacteria combinations to facilitate clinical interpretation. These modifications are included in a separate annex of this document. It is necessary to compare other susceptibility testing methods (e.g. disc diffusion or diagnostic test devices) with this reference method for validation, in order to ensure comparable and reliable results.

Committee	CH/212
DocumentType	Standard
ISBN	9780580523823
Pages	30
PublisherName	British Standards Institution
Status	Current
Supersedes	BS EN ISO 20776-1:2006

Standards	Relationship
EN ISO 20776-1:2020	Identical
ISO 20776-1:2019	Identical

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BS EN ISO 20776-1:2020

Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices Broth micro-dilution reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases

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