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CLSI LA4 A4 : 4ED 2003

Superseded

Superseded

A superseded Standard is one, which is fully replaced by another Standard, which is a new edition of the same Standard.

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superseded

A superseded Standard is one, which is fully replaced by another Standard, which is a new edition of the same Standard.

BLOOD COLLECTION ON FILTER PAPER FOR NEWBORN SCREENING PROGRAMS

Superseded date

25-07-2007

Published date

12-01-2013

Abstract
Committee Membership
Foreword
1 Scope
   1.1 Specimen Quality
   1.2 Specimen Acceptability
   1.3 Applications
2 Source of Blood
   2.1 Heel
   2.2 Other
   2.3 Unacceptable Sources
3 Techniques for Blood Collection on Filter Paper
   3.1 Heelstick (Method of Choice)
   3.2 Capillary Tube
   3.3 Dorsal Hand Vein
   3.4 Umbilical Venous Catheter (UVC) or Umbilical
       Arterial Catheter (UAC)
   3.5 Specimen Handling and Transport
4 Specifications for Specimen Matrix
   4.1 Collection Paper Specifications
   4.2 Paper Performance Characteristics
   4.3 Ink Specifications
   4.4 Packaging Precautions
5 Specimen Collection Device
   5.1 Minimum Preprinted Information
   5.2 Specimen Collection Device
6 Blood Spot Handling for DNA Analysis
   6.1 Contamination
   6.2 Specimen Contact
7 Extended Storage of Residual Specimens
References
Appendix A How to Collect and Acceptable Blood Spot
           Specimen (Detachable)
Appendix B Protocol for Testing the Absorption
           Characteristics of Filter Paper
Appendix C Filter Paper Specifications
Appendix D Blood Spot Drying Device
Summary of Comments and Committee Responses
Summary of Delegate Comments and Working Group Responses
The Quality System Approach
Related NCCLS Publications

Aims to improve and ensure the quality of blood spots collected from newborns. Unacceptable and poor quality specimens place an unnecessary burden on the screening facility, cause unnecessary trauma to the infant and anxiety to the infant's parents, potentially delay the detection and treatment of the affected infant, and could contribute to a missed or late diagnosed case.

DevelopmentNote
Supersedes NCCLS LA4 A3. (09/2003)
DocumentType
Miscellaneous Product
PublisherName
Clinical Laboratory Standards Institute
Status
Superseded
SupersededBy
Supersedes

CLSI I/LA27 P : 1ED 2005 NEWBORN SCREENING FOLLOW-UP
CLSI NBS06 A : 1ED 2013 NEWBORN BLOOD SPOT SCREENING FOR SEVERE COMBINED IMMUNODEFICIENCY BY MEASUREMENT OF T-CELL RECEPTOR EXCISION CIRCLES
CLSI MM13 A : 1ED 2006 COLLECTION, TRANSPORT, PREPARATION, AND STORAGE OF SPECIMENS FOR MOLECULAR METHODS
CLSI I/LA27 A : 1ED 2006 NEWBORN SCREENING FOLLOW-UP
CLSI MM13 P : 1ED 2005 COLLECTION, TRANSPORT, PREPARATION, AND STORAGE OF SPECIMENS FOR MOLECULAR METHODS
CLSI C50 P : 1ED 2007 MASS SPECTROMETRY IN THE CLINICAL LABORATORY: GENERAL PRINCIPLES AND GUIDANCE

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