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ASTM E 1242 : 2023

Current

Current

The latest, up-to-date edition.

Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis

Available format(s)

Hardcopy , PDF

Language(s)

English

Published date

02-15-2023

US$55.00
Excluding Tax where applicable

Committee
E 50
DocumentType
Standard Practice
Pages
2
PublisherName
American Society for Testing and Materials
Status
Current
Supersedes

1.1This practice covers a procedure for estimating the fathead minnow (Pimephales promelas) 96-h LC50 of nonreactive (that is, covalently bonded without unsaturated residues) and nonelectrolytic (that is, require vigorous reagents to facilitate substitution, addition, replacement reactions and are non-ionic, non-dissociating in aqueous solutions) organic chemicals acting solely by narcosis, also referred to as Meyer-Overton toxicity relationship.2

1.2This procedure is accurate for organic chemicals that are toxic due to narcosis and are non-reactive and non-electrolytic. Examples of appropriate chemicals are: alcohols, ketones, ethers, simple halogenated aliphatics, aromatics, and aliphatic substituted aromatics. It is not appropriate for chemicals whose structures include a potential toxiphore (that structural component of a chemical molecule that has been identified to show mammalian toxicity, for example CN is known to be reponsible for inactivation of enzymes, NO2 for decoupling of oxidative phosphorylation, both leading to mammalian toxicity). Examples of chemicals inappropriate for this practice are: carbamates, organophosphates, phenols, beta-gamma unsaturated alcohols, electrophiles, and quaternary ammonium salts.

1.3This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

ASTM E 729 : 1996 : R2014 Standard Guide for Conducting Acute Toxicity Tests on Test Materials with Fishes, Macroinvertebrates, and Amphibians
ASTM E 1023 : 1984 : R2014 Standard Guide for Assessing the Hazard of a Material to Aquatic Organisms and Their Uses
ASTM E 943 : 2023 Standard Terminology Relating to Biological Effects and Environmental Fate
ASTM E 943 : 2008 : R2014 Standard Terminology Relating to Biological Effects and Environmental Fate (Withdrawn 2023)
ASTM E 1023 : 2023 Standard Guide for Assessing the Hazard of a Material to Aquatic Organisms and Their Uses

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